ART Studies: Review of the health of adults conceived with and without Assisted Reproductive Technologies
Synopsis
It is generally believed that common adult onset disorders (particularly cardiovascular and respiratory diseases) begin in early life, possibly even before birth. Children born following the use of assisted reproductive technologies (ART) might be in a specific risk category because of the techniques used to enable successful ART/pregnancies. However, there are very few studies on adults born following ART.
The 2009-2011 retrospective cohort study, “Comparison of health and development of young adults born with and without assisted conception”, is the largest in-depth study anywhere in the world of people aged 18 years and over who were conceived with ART. The aim of the study was to compare the physical and mental health, educational achievements, and social development of young adults conceived with and without ART. Telephone interviews were conducted with 1524 mothers (reporting on 1573 offspring), and 1096 young adults.
The young adults that participated in the 2009 – 2011 telephone interviews have been invited to take part in the 2016-2017 CHART (Clinical review of the Health of 22-35 year olds conceived with and without Assisted Reproductive Technologies) Study. CHART is a clinical review investigating the respiratory, cardiac and metabolic health, and general wellbeing of the participants. Recruitment began in June 2016.
Summary
Study name |
IYAGS: Comparison of health and development of young adults born with and without assisted conception CHART Study: Clinical review of the Health of 22-35 year olds conceived with and without Assisted Reproductive Technologies |
Study abbreviation | IYAGS and CHART Study |
Current principal investigator/s | Professor Jane Halliday |
Cohort representative (study contact) | Dr Sharon Lewis (CHART) |
Postal address | Public Health Genetics, Murdoch Childrens Research Institute, 50 Flemington Rd, Parkville, VIC 3052 |
Phone | +613 9936 6766 |
chart.study@mcri.edu.au | |
Primary Institution | Murdoch Children’s Research Institute |
Collaborating Institution/s |
IYAGS: Royal Womens Hospital / Melbourne IVF; Victorian Perinatal Data Collection Unit (VPDCU); Epworth Hospital / Monash IVF CHART: Monash IVF; Melbourne IVF; Hudson Institute of Medical Research; Monash University |
Major funding sources |
IYAGS: National Health and Medical Research Council; Jack Brockhoff Foundation CHART: National Health and Medical Research Council – full study; Murdoch Childrens Research Institute; Royal Children’s Hospital Foundation – pilot; Monash Research & Education Foundation (MREF) – pilot; Melbourne IVF – pilot |
Study website |
mcri.edu.au/research/projects/assisted-reproductive-technologies |
Key reference |
IYAGS: Wilson, C., Hammarberg, K., Bruinsma, F., Berg, T., Amor, D., Sanson, A., Fisher, J.R. and Halliday, J. (2013). Health and development of ART conceived young adults: a study protocol for the follow-up of a cohort. Reprod Health, 10: 15. doi: doi: 10.1186/1742-4755-10-15 CHART: Lewis, S., Kennedy, J., Burgner, D., McLachlan, R., Ranganathan, S., Hammarberg, K., Saffery, R., Amor, D.J., Cheung, M.M.H., Doyle, L.W., Juonala, M., Donath, S., McBain, J. and Halliday, J. (2017). Clinical review of 24-35 year olds conceived with and without in vitro fertilization: study protocol. Reprod Health, 14(1): 117. doi: 10.1186/s12978-017-0377-3 |
Are data available outside study team? | No |
Study focus |
IYGS: Health and development of young adults born with and without assisted conception CHART: Clinical review of respiratory, cardiac and metabolic health |
Sampling frame |
IYGS:
CHART:
|
Year commenced |
IYGS: 2008 (recruitment and data collection commenced in 2009) CHART: 2014 (pilot) 2016-2017 (full study) |
Commencement sample |
IYGS:
CHART Target Sample (recruitment ongoing):
|
Intergenerational? | No |
Imaging |
CHART:
|
Linkage | No |
Biosamples? |
CHART:
|
Ethics approvals or requirements? |
IYGS: This project only (Specific consent) CHART: This project only (Specific consent) |
Waves
Wave | Year | Age (mean, range) | Eligible sample |
---|---|---|---|
IYAGS (telephone interview) | 2009-2011 | 18-28 years (offspring) | 656 IVF mothers and 547 offspring 868 non-IVF mothers and 549 offspring |
CHART (clinical review) | 2014-2017 | 22-35 years | 540 (ART); 532 (Non-ART) |