Mater-University of Queensland Study of Pregnancy
Synopsis
The Mater Misericordiae Mothers’ Hospital-University of Queensland Study of Pregnancy began as a prospective study of 8,556 pregnant women interviewed after their first clinic visit. The initial phase of data collection commenced in 1981. Later phases have collected data on both mother and child a various times after the children were born: when the children were around the ages of six months, five years, fourteen and twenty-one years old.
Between 2009 and 2012, we followed-up with the Mothers separately to focus on the midlife experiences of women. The 30-year phase, between 2011 and 2014, followed-up with the children, rather, young adults of the study. This phase of the study was especially interested in the specific developmental path and risk factors for conditions such as obesity, metabolic syndrome and diabetes, and mental health.
In 2015 – 2019 a new phase of the study was conducted this time looking at the third generation of participants, the grandchildren of our original Mothers. The phase investigated the generational and developmental pathways of childhood and adolescent obesity and the transmission of antisocial behaviour across three generations. MUSP is one of only a handful of studies worldwide that is able to examine whether maternal pregnancy, early childhood and puberty are critical periods for the development of obesity and behavioural problems.
In 2020 an exciting new phase of the study commenced. This phase of the study will investigate the incidence of child and adolescent experiences of victimisation in Australia. This study will explore the extent to which children and adolescents experience victimisation in Australia and the factors that contribute to this victimisation. This study will address widespread concerns about the experiences of violence by Australian children. No previous Australian population-based studies have addressed this issue.
Summary
Study name | The Mater-University of Queensland Study of Pregnancy |
Study abbreviation | MUSP |
Current principal investigator/s | Prof. Jake Najman, Dr William Bor, Prof. Gail Williams, A/Prof. Alexandra (Zandy) Clavarino, A/Prof. Abdullah Al Mamun, Prof. Rosa Alati, A/Prof. James Scott, A/Prof Tara McGee |
Current project manager | Ms Shelby Marrington |
Cohort representative (study contact) | Prof. Jake Najman |
Postal address | School of Public Health, Level 2, Public Health Building (887), Corner of Herston Road & Wyndham Street, The University of Queensland, Herston QLD 4006, Australia |
Phone | +61 7 3365 5180 |
Primary Institution | The University of Queensland |
Collaborating Institution/s | The Mater Hospital |
Major funding sources | This project has been funded by The National Health and Medical Research Council (NHMRC) and the Australian Research Council (ARC), via competitive research grants. |
Study website | https://social-science.uq.edu.au/mater-university-queensland-study-pregnancy |
Key reference |
Najman JM, Bor W, O’Callaghan M, Williams GM, Aird R and Shuttlewood G. 2005. ‘Cohort profile: The Mater-University of Queensland Study of Pregnancy (MUSP)’. International Journal of Epidemiology, 34(5), 992-997. doi: 10.1093/ije/dyi119 Najman JM, Alati R, Bor W, Clavarino A, Mamun A, McGrath JJ, McIntyre D, O’Callaghan M, Scott J, Shuttlewood G, Williams GM and Wray N. 2015. ‘Cohort Profile Update: The Mater-University of Queensland Study of Pregnancy (MUSP).’ International Journal of Epidemiology, 44(1), 78-78f. doi: 10.1093/ije/dyu234 |
Are data available outside study team? | Collaborations can be sought by contacting Prof Jake Najman. Agreement by all principal investigators is needed for collaboration. Data is made available on a case-by-case basis. |
Study focus | MUSP has become a longitudinal study of growth, development and ageing with an emphasis on the generational transmission of a wide range of factors impacting on adult health outcomes. Some of the topic areas include (but are not limited to), mental illness, substance use, obesity (and body mass index [BMI]), cardiovascular disease (CVD), and social determinants of health. |
Sampling frame | MUSP began as a cohort study of some 8556 consecutive, pregnant women recruited at their first antenatal visit at the Mater Hospital in Brisbane, Australia. |
Year commenced | 1981 -1983 (Recruitment) |
Commencement sample | Mothers (Gen1) = 6753 Children (Gen2) = 7223 |
Intergenerational? | Mothers = Generation 1 (Gen1) Children = Generation 2 (Gen2) Offspring of Gen2 = Generation 3 (Gen3) |
Linkage |
2000 – Child Protection Data 2022 – National Death Index (AIHW) |
Biosamples? | Buccal (Gen2), blood (Gen2), urine (Gen2),saliva (Gen3) |
Ethics approvals or requirements? |
|
Waves
Wave | Year | Age (mean, range) | Eligible sample |
---|---|---|---|
1 Entry to the study
|
1981-1984 | 25.0 (13.2-46.9) |
Mothers (Gen1) N = 6753 Children (Gen2) N = 7223 |
2 3-5 days after birth
|
1981-1984 | 25.4 (13.4-47.4) |
Mothers (Gen1) N = 6753 Children (Gen2) N = 7223 |
3 6 months after birth
|
1981 – 1985 |
26.1 (14.0-48.1) 0.6 (0.3-2.0) |
Mothers (Gen1) N = 6753 Children (Gen2) N = 7223 |
4 5 years after birth
|
1986 – 1989 |
31.3 (18.6-52.4) 5.6 (3.9-8.0) |
Mothers (Gen1) N = 6678 Children (Gen2) N = 7144 |
5 14 years after birth
|
1994 – 1997 |
39.7 (27.1-61.2) 13.9 (12.1-15.5) |
Mothers (Gen1) N = 6538 Children (Gen2) N = 6988 |
6 21 years after birth
|
2001 – 2004 |
46.6 (34.3-67.4) 20.6 (18.2-24.3) |
Mothers (Gen1) N = 6402 Children (Gen2) N = 6824 |
7 27 years after birth
|
2008 – 2012 | 53.3 (40.8-73.9) | Mothers (Gen1) N = 6236 |
8 30 years after birth
|
2011 – 2014 | 30.3 (27.8-33.5) | Children (Gen2) N = 6721 |
9 MUSPH
|
2013 – 2014 | 31.4 (29.1,33.5) |
Participants with Hallucinations N =1108 Controls N = 550 |
10 MUSP Gen3
|
2015 – 2019 | 6.9 (2.0-19.1) |
Gen 3 children (aged 2yrs old and up) Approx. N = 3250 |
11 MUSP G3 Child Victimisation
|
2020 – 2023 | TBC |
Gen 3 children (aged 2yrs old and up) |