The Adolescence to Emerging Adulthood (A2EA) Study (formerly the Orygen Adolescent Development Study) is a prospective longitudinal study that aims to address core questions regarding biological and environmental risk factors for the development of depression and other psychopathologies with common onset during adolescence. 


Study name Adolescence to Emerging Adulthood (A2EA) Study
Study abbreviation A2EA
Current principal investigator/s Prof. Nicholas Allen, A/Prof Sarah Whittle, Dr Julian Simmons
Current project manager Dr Julian Simmons
Cohort representative (study contact) Dr Julian Simmons
Postal address Melbourne Neuropsychiatry Centre, Level 3 Alan Gilbert Building, 161 Barry Street, Carlton, Victoria 3053
Phone +61 3 90358318
Primary Institution The University of Melbourne
Collaborating Institution/s The University of Oregon
Major funding sources The Australian Research Council, The National Health and Medical Research Council, The Colonial Foundation 
Key reference No study protocol was published for this study, however the selection/recruitment strategy is described in the following publication –
Yap, MB, Allen, NB, O’Shea M, di Parsia, P, Simmons JG, Sheeber L. Early adolescents’ temperament, emotion regulation during mother-child interactions, and depressive symptomatology. Dev Psychopathol. 2011;23(1): 267-282. doi: 10.1017/S0954579410000787
Are data available outside study team? Yes, but requirement that analyses and arising publications will be carried out in collaboration with at least one of the principal investigators.
Study focus Developmental psychopathology
Sampling frame Community based grade 6 children. Selection was based on temperament scores as risk factors for emotional and behavioural disorders. 
Year commenced 2003 – 2012
Commencement sample 245 
Intergenerational? No 
Imaging MRI, DWI and fMRI at three time points. 
Linkage No
Biosamples? Buccal swabs, saliva at single time point. 
Ethics approvals or requirements? Specific consent


Wave Year Age (mean, range) Eligible sample
0  2004 10-12 years 2453 (screened)
1  2004 – 2005 12.46, 11-13 years 245
2  2007 – 2008 15.2, 14-15 years 241
3  2008 – 2010 16.4, 15-17 years 232
4  2011 – 2012 18.8, 16-20 years 225
5  2019 TBC TBC